The vascular system, also called the circulatory system, is a network of blood vessels – arteries, veins and capillaries – that transport blood to and from the heart. The blood vessels pick up oxygen from the lungs and then transport it to the muscles and organs. The circulatory system is divided into the pulmonary circulation and the systemic circulation. The systemic circulation transports blood to all parts of the body except the lungs. Oxygen-rich blood filled with nutrients is carried through the arteries throughout the body. Oxygen-depleted blood flows back to the heart through the veins where it picks up oxygen to start the cycle all over again. The pulmonary circulation is a part the cardiovascular system comprised of a network of blood vessels located between the heart and lungs. In pulmonary circulation oxygen-depleted blood is carried away from the heart and to the lungs, and then returned as oxygen-rich blood back to the heart.
Impaired blood vessels obstruct the flow of blood filled with oxygen to reach tissues. Injury or damage to blood vessels can lead to problems such as weakened blood vessels that burst and cause bleeding, blood clots, and atherosclerosis, also known as hardening of the arteries due to the buildup of fatty deposits on the inner walls of arteries.
Vascular Disease is a general term for any cardiovascular disorder affecting the circulatory system, primarily diseases of the arteries, veins and lymph vessels but also blood disorders that block circulation. Peripheral Vascular Disease (PVD) refers to disorders of blood vessels outside the heart that involve the peripheral circulation rather than cardiac circulation. Peripheral Artery Disease (PAD) is one of the most common forms of PVD. Although the terms PVD and PAD are often used interchangeably, they are distinct. PVD consists of diseases of both peripheral arteries and peripheral veins. PVD of the arteries and veins are sometimes linked with common risks, but they differ in their symptoms. For example, PAD is characterized primarily by intermittent claudication due to insufficient blood flow. Intermittent claudication is experienced as arm or leg pain or cramping in the arms or legs, especially in the calf, during walking or exercise that disappears with rest. Venous conditions, or disorder of the veins, such as peripheral vein disease include varicose veins and spider veins. PVD also encompasses cerebrovascular disease, a condition where blood vessels in the brain are injured or damaged.
Major Types of Peripheral Vascular Diseases
Risks of Vascular Disease
Risks of most vascular diseases include:
Symptoms of Vascular Disease
Symptoms are specific to each type of peripheral vascular disease.
Diagnosis of Vascular Disease
Diagnosis of a vascular disease can be difficult because of the wide variety of symptoms associated with various vascular disorders. Diagnosis is usually based on specific symptoms, family history, and a physical examination performed by a specialist. Blood flow in the legs or blood pressure may need to be examined if a peripheral vascular disease is suspected.
The physical exam may vary slightly for different circulatory conditions, depending on the type of vascular disease thought to exist. Abnormal sounds of blood flow on the neck may indicate that cerebrovascular disease is present.
Additional tests and exams may include:
Treatment of Vascular Disease
Treatment of Vascular Disease involves lifestyle changes and therapies, including medications and sometimes surgery and other procedures, that are specific for each condition.
Peripheral Artery Disease (PAD)
As a person ages, plaque — the build-up of fat and cholesterol deposits – tends to form on the inside walls of peripheral arteries (the blood vessels outside the heart), just as it does in the coronary arteries that transport blood to the heart. The accumulation of plaque over time causes the artery to narrow, limiting blood flow. Reduced blood flow to any tissues in the body due to clogged arteries is called ischemia. Clogged peripheral arteries can lead to various types of vascular disease. In peripheral artery disease (PAD), blockage in the arteries outside the heart can restrict blood flow to the legs, causing leg pain or cramps during activity (claudication) and increasing the risk for a heart attack or stroke. Nearly 5% of Americans over the age of 50 have PAD.
Most people with PAD—even if they do not have leg symptoms—are unable to walk as fast or as far as they could before developing claudication.
Risks of Peripheral Artery Disease
Signs and Symptoms of Peripheral Artery Disease
Diagnosis of Peripheral Artery Disease
Treatment of PAD
Lifestyle changes
Medication
Procedures and Surgeries to improve the blood circulation to the legs and the ability to walk
Risk for Complications
Peripheral artery disease is associated with increased risk for arterial disease involving the coronary arteries within the brain.
Aneurysm
An aneurysm is an abnormal bulge or ballooning in the wall of a blood vessel caused by the weakening of the blood vessel wall. An aneurysm usually forms in the aorta (aortic aneurysm), the primary blood vessel leaving the heart. The two types of aortic aneurysm are a thoracic aortic aneurysm (part of aorta in the chest) and abdominal aortic aneurysm. An abdominal aortic aneurysm can involve arteries above the kidneys (suprarenal aneurysm), the main kidney (renal) arteries (juxtarenal aneurysm), or arteries below the kidneys (infrarenal aneurysm).
Small aneurysms are not generally dangerous, but they increase a person’s risk for:
Symptoms of Aortic Aneurysm
Diagnosis
Aneurysms are usually diagnosed by chance during exams or tests performed to screen for other conditions.
Risk Factors for Abdominal Aneurysms
Treatment of an Aortic Aneurysm
Renal (Kidney) Artery Disease
Renal Artery Disease, usually caused by atherosclerosis of renal arteries disease, occurs in people with generalized vascular disease. A blockage in the kidney arteries can lead to renal artery disease (stenosis), characterized by symptoms of uncontrolled high blood pressure, congestive heart failure, and abnormal kidney function.
Carotid Artery Disease
Carotid arteries are on either side of the neck. Carotid artery disease develops when atherosclerosis occurs in the carotid arteries, located on either side of the neck, that transport oxygen-rich blood to the brain. The accumulation of plaque can obstruct blood flow to the brain or lead to the formation of a blood clot which dislodges and travels to the brain, causing a stroke or blindness.
Raynaud’s Phenomenon (Raynaud’s Disease or Raynaud’s Syndrome)
Raynaud’s phenomenon involves spasms of the small arteries of the fingers and, in some cases, the toes, caused by excitement or exposure to cold. By temporarily slowing or stopping blood supply to the area, Raynaud’s Disease causes the skin to appear white or bluish and cold or numb. Symptoms of Raynaud’s Syndrome are sometimes associated with underlying diseases such as lupus, rheumatoid arthritis, or scleroderma.
Buerger’s Disease
Buerger’s Disease usually affects the small and medium sized arteries, veins, and nerves. As the arteries of the arms and legs become narrowed or blocked, blood supply to the fingers, hands, toes and feet is reduced. Symptoms include pain in the legs and feet, especially, and arms and hands, even at rest. If the blood flow obstruction is severe, the tissue may die (gangrene), requiring amputation of the fingers and toes. Superficial vein inflammation and symptoms seen in Raynaud’s disease are frequently observed in patients with Buerger’s Disease. Tobacco use or exposure appears to be a triggering factor in Buerger’s Disease.
Common Peripheral Venous Diseases include:
Blood clots in the veins
Chronic venous insufficiency — a condition in which damaged vein valves or a DVT causes long-term pooling of blood and swelling in the legs.
Causes of Blood Clots in the Veins
Deep Vein Thrombosis (DVT)
Deep Vein Thrombosis (DVT) refers to a blood clot that forms in a vein deep within the body
As blood thickens and clumps together. Deep vein blood clots usually develop in the lower leg or thigh, although they may form in other areas. A DVT that breaks off and becomes a loose clot is called an embolus. In a pulmonary embolism, an embolus travels through the bloodstream where it reaches an artery in the lungs, eventually obstructing blood flow and damaging the lungs. A pulmonary embolism may impair other organs in the body and, in severe cases, be fatal.
Blood Clotting Disorders
Blood clotting disorders are diseases that in which the blood is more likely to form blood clots in the arteries and veins. These conditions include:
Chronic Vein Disease and Chronic Venous Insufficiency (CVI)
Chronic vein disease is a vein disorder that typically affects the legs. As the vein walls become weakened and stretched over time, the veins bulge out and twist. Chronic Venous Insufficiency (CVI) develops if the veins are no longer able to pump sufficient blood back to the heart, instead causing long-term pooling of blood and swelling in the legs. If left untreated, fluid will leak into the surrounding tissues in the ankles and feet, eventually leading to skin breakdown and ulceration.
Varicose veins are the most common early sign of vein disease, with about 1/3 of adult women affected. Of the nearly 2.5 million people in the United States diagnosed with CVI, 20% of them will develop ulcers caused by leg vein disease.
Causes of Chronic Vein Disease
Symptoms of Chronic Vein Disease
Chronic vein disease may not cause any symptoms at first, but as the disease progresses it can lead to symptoms that make everyday tasks difficult. Like heart failure, chronic lung disease, or arthritis, CVI can diminish quality of life. The main symptoms include:
Risks for Chronic Vein Disease
Treatment of Venous Vascular Diseases
Prognosis of DVT
DVT rarely causes sudden death, and nearly 96% of patients survive after their first DVT episode. However, up to 30% of those who have a DVT or pulmonary embolism will suffer another episode within 10 years, usually during the first 6 to 12 months. Women have a lower risk for recurrent DVT than men.
Lymphedema
The lymphatic system, an extensive network of lymph vessels and lymph nodes, comprises a separate circulatory system from the vascular system. The lymphatic system helps regulate the immune system’s function to protect the body from foreign substances. Lymphedema refers to an abnormal build-up of fluid that causes swelling, generally in the arms or legs.
Causes
Symptoms
Lymphedema symptoms include:
Diagnosis
Diagnostic tests used to detect lymphedema include:
Complications
Treatments
To decrease the risk of vascular disease, see your physician for regular check-ups and make lifestyle changes to reduce risks and take the appropriate medications prescribed by your doctor.
References
WebMD.com
Mayo Clinic
Medline Plus
Wikipedia.com
National Heart Lung and Blood Institute
Cleveland Clinic
American Heart Association
HeartHealthyWomen.com
www.medicinenet.com