Irina Ianculescu, Ph.D.
Dr. Ianculescu received her PhD in Genetic, Molecular and Cellular Biology from the University of Southern California. Her doctoral dissertation focused on the role of histone acetyltransferases in androgen receptor mediated transcription in prostate cancer cells. Prior to that, she worked as a research associate in the department of Diabetes, Endocrinology and Metabolism at the Beckman Research Institute at the City of Hope. Presently, at the Pacific Meso Center, her work focuses on investigating gene expression patterns in mesothelioma. She has over ten years experience applying molecular biology techniques to the understanding and treatment of various diseases including cancer and diabetes.
- Ph.D. Genetic, Molecular and Cellular Biology 2011
University of Southern California, Los Angeles, CA
- B.A. Cell and Molecular Biology 2000
Occidental College, Los Angeles, CA
Bittencourt D, Wu DY, Jeong KW, Gerke DS, Herviou L, Ianculescu I, Chodankar R, Siegmund KD, Stallcup MR.2012 G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes. Proc Natl Acad Sci U S A. 109(48):19673-8.
Ianculescu I, Wu DY, Siegmund KD, and Stallcup MR. 2012 Selective Roles for CBP and p300 as Coregulators for Androgen-Regulated Gene Expression. J Biol Chem 287(6):4000 – 13.
Ou CY, LaBonte MJ, Manegold PC, So AYL, Ianculescu I, Gerke DS, Yamamoto KR, Ladner RD, Kahn M, Kim JH and Stallcup MR. 2011 A coactivator role of CARM1 for the dysregulated b-catenin activity in colorectal cancer cell growth and gene expression. Mol Can Res 9(5):660-70.
Lee DY, Ianculescu I, Purcell D, Zhang X, Cheng X, Stallcup MR. 2007 Surface scanning mutational analysis of protein arginine methyltransferase 1: roles of specific amino acids in methyltransferase substrate specificity, oligomerization, and coactivator function. Mol Endocrinol 21(6):1381-93.
Shan L, Vincent J, Brunzelle JS, Dussault I, Lin M, Ianculescu I, Sherman MA, Forman BM, Fernandez EJ. 2004 Structure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism. Mol Cell 16(6):907-17.