Jenny T. Mao, M.D.

Associate Professor of Medicine

Clinical Interest:
Asthma
Critical Care
General Pulmonology
Lung Cancer Center & Chest Malignancy
Pulmonary Procedures

Biography

Background

Dr. Mao received her M.D. degree from UCLA School of Medicine in 1991, where she went on to complete her internship and residency training in General Internal Medicine and subspecialty fellowship training in Pulmonary and Critical Care Medicine. In 1997 she joined the faculty of the Division of Pulmonary and Critical Care Medicine. In 1999 she established the current LIFE-Lung (fluorescence) bronchoscopy program for early detection of precancerous abnormalities in the airway. In the following year, she also established the lung cancer chemoprevention program at UCLA for high-risk population. The program integrates a comprehensive early screening approach using chest CT scan and fluorescence bronchoscopy with chemoprevention. She belongs to a highly interactive group of basic science lung cancer researchers, epidemiologists, radiologists and thoracic medical and surgical oncologists, all working together within the structure of the UCLA Thoracic Oncology Program, Jonsson Comprehensive Cancer Center/UCLA, and the UCLA Lung Cancer Specialized Program of Research Excellence (SPORE).

Dr. Mao has extensive basic science training background in molecular biology and tumor immunology. Her basic science training in tumor immunology was carried out in the laboratory of Dr. Steven Dubinett and focused on the biology of cyclooxygenase-2 and lung cancer immunity. Since joining the faculty, she has focused on translational clinical research and independently developed and directs two phase II pilot studies examining the use of Celecoxib as a lung cancer chemopreventive agent. In recent years she received a NCI/K23 award, a TRDRP IDEA Award and a Cancer Research Foundation of America award for career development and early-phase clinical trials in the area of lung cancer chemoprevention and early detection. During the second year of her K23 award, she obtained a multi-million dollar NCI/UO1 grant to evaluate Celecoxib for lung cancer chemoprevention in ex-smokers, receiving the top score in the country.

She is Board certified in Internal Medicine, Pulmonary, and Critical Care medicine. She is an experienced bronchoscopist, mentored in the use of the LIFE system by Dr. Stephen Lam at the British Columbia Cancer Agency in Vancouver. She has considerable experience in pulmonary clinical research, both investigator-initiated and industry-sponsored trials, has independently developed and directed several investigator initiated trials, including the use of retinoid therapy for emphysema. She is also the UCLA representative on the NCI/EDRN/ SPORE (lung cancer proteomics committee (LCPC) and the UCLA site PI for the Lung Cancer Biomarker and Chemoprevention Committee (LCBCC) studies including the Iloprost chemoprevention study. She has published numerous research articles in high impact journals and authored many book chapters. She has been an invited speaker at multiple regional, national and international meetings and serves as a referee on many high impact journals and grants review committees.

Articles/Publications

Mao JT, Tsu IH, Dubinett SM, Adams B, Sarafian T, Baratelli F, Roth MD, Serio KJ “Modulation of pulmonary leukotriene B4 production by cyclooxygenase-2 inhibitors and lipopolysaccharide.” Clinical cancer research: an official journal of the American Association for Cancer Research. 2004; 10(20): 6872-8.
http://www.ncbi.nlm.nih.gov

Pold M, Zhu LX, Sharma S, Burdick MD, Lin Y, Lee PP, Pold A, Luo J, Krysan K, Dohadwala M, Mao JT, Batra RK, Strieter RM, Dubinett SM
“ Cyclooxygenase-2-dependent expression of angiogenic CXC chemokines ENA-78/CXC Ligand (CXCL) 5 and interleukin-8/CXCL8 in human non-small cell lung cancer.” 2004; 64(5): 1853-60.
http://www.ncbi.nlm.nih.gov

Mao JT, Roth MD, Serio KJ, Baratelli F, Zhu L, Holmes EC, Strieter RM, Dubinett SM
“ Celecoxib modulates the capacity for prostaglandin E2 and interleukin-10 production in alveolar macrophages from active smokers. 2003; 9(16 Pt 1): 5835-41.”
http://www.ncbi.nlm.nih.gov